Iowa State University researchers have described with single-molecule precision how copper ions cause prion proteins to misfold and seed the misfolding and clumping of nearby prion proteins.
Certain bonds connecting biological cells get stronger when they’re tugged. Those bonds could help keep hearts together and pumping; breakdowns of those bonds could help cancer cells break away and spread.
Five projects have been chosen as the initial recipients of the College of Liberal Arts and Science’s Signature Research Initiative. -Read complete press release-
Sanjeevi Sivasankar knows a lot about how the healthy cells in your body stick together. He and his research team have studied cell adhesion proteins called cadherins. They’ve developed an instrument that takes 3-D measurements for single-molecule studies of cell adhesion.
The human body has more than a trillion cells, most of them connected, cell to neighboring cells. How, exactly, do those bonds work? What happens when a pulling force is applied to those bonds? How long before they break?
By blending optical and atomic force microscope technologies, Iowa State University and Ames Laboratory researchers have found a way to complete 3-D measurements of single biological molecules with unprecedented accuracy and precision.
Observation of a scientific rule being broken can sometimes lead to new knowledge and important applications.
Sanjeevi Sivasankar was looking for a better tool to study how cells adhere to each other. Cells have surface proteins, called cadherins, that help them stick together. Different kinds of cells have different kinds of cadherins.
Iowa State University researchers will use grants of state money to develop an instrument that reveals single molecules, test technology that can detect food contamination, design taller wind turbine towers and advance seven other projects with potential to grow the state's economy.